Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

被引：21
作者：
Elmallah, Mohammed I. Y. [1 ,2 ]
Micheau, Olivier [2 ,3 ]
机构：
[1] Helwan Univ, Fac Sci, Dept Chem, Cairo 11790, Egypt
[2] Inst Natl Sante & Rech Med, UMR866, F-21079 Dijon, France
[3] Unite Format & Rech, Sci Sante, F-21079 Dijon, France
来源：
MARINE DRUGS | 2015年 / 13卷 / 11期
关键词：
TNF; TRAIL; Apoptosis; resistance; cancer; marine drugs; alkaloids; carotenoids; sesquiterpenes; macrolactones; NF-KAPPA-B; COLON-CANCER CELLS; DEATH RECEPTOR 5; HEPATOCELLULAR-CARCINOMA CELLS; BIOACTIVE NATURAL-PRODUCTS; SENSITIZES GLIOMA-CELLS; DR5; UP-REGULATION; DOWN-REGULATION; MEDIATED APOPTOSIS; C-FLIP;
D O I：
10.3390/md13116884
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
引用
收藏
页码：6884 / 6909
页数：26
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