Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

被引：190

作者：

Padmavathi, V. ^{[1
]}

Reddy, G. Sudhakar ^{[1
]}

Padmaja, A. ^{[1
]}

Kondaiah, P. ^{[2
]}

Ali-Shazia ^{[2
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期

关键词：

1,3,4-Oxadiazoles; 1,3,4-Thiadiazoles; 1,2,4-Triazoles; Antimicrobial activity; Cytotoxicity; ANTIINFLAMMATORY ACTIVITY; 5-LIPOXYGENASE; CYCLOOXYGENASE; ANTIBACTERIAL; DERIVATIVES; GROWTH;

D O I：

10.1016/j.ejmech.2008.10.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2106 / 2112

页数：7

共 33 条

[21] Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles [J].

Padmavathi, V. ;

Thriveni, P. ;

Reddy, G. Sudhakar ;

Deepti, D. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (05) :917-924

[22] Synthesis of a new class of keto-linked bis heterocycles [J].

Padmavathi, V ;

Reddy, BJM ;

Reddy, BCO ;

Padmaja, A .

TETRAHEDRON, 2005, 61 (09) :2407-2411

[23] Synthesis of thiadiazoles, triazoles and oxadiazoles from sulfonyl acetic acids via a common route [J].

Padmavathi, V ;

Thriveni, P ;

Reddy, BJM ;

Padmaja, A .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (01) :113-116

[24] Aroylethenesulfonylacetic acid methyl ester - A synthon for novel sulfone linked bis heterocycles [J].

Padmavathi, Venkatapuram ;

Mohan, Annaji Venkata Nagendra ;

Mahesh, Konda ;

Padmaja, Adivireddy .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (06) :815-820

[25] Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives [J].

Padmavathi, Venkatapurarm ;

Subbaiah, Dandu Rangayapalle Chinna Venkata ;

Mahesh, Konda ;

Lakshmi, Thunga Radiia .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (12) :1704-1709

[26] SOME OBSERVATIONS ON THE REACTION OF ALKALI THIOCYANATES WITH EPOXIDES [J].

PRICE, CC ;

KIRK, PF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (10) :2396-2400

[27]

REDDY DB, 1988, ORG PREP PROCED INT, V20, P83

[28]

SINGH IP, 1986, EUR J MED CHEM, V21, P267

[29]

TINPERCIUC B, 1999, FARM BUCHUREST, V47, P77

[30] 6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen:: synthesis, characterization and evaluation of anti-inflammatory activity [J].

Tozkoparan, B ;

Gökhan, N ;

Aktay, G ;

Yesilada, E ;

Ertan, M .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (7-8) :743-750

← 1 2 3 4 →