Effects of Maternal Exposure to Diethylstilbestrol on Epididymal Development in Rat Offspring

被引：3

作者：

Yamamoto, Masako ^{[1
]}

Kohara, Shinya ^{[1
]}

Kobayashi, Tetsuo ^{[1
]}

Shirai, Mitsuyuki ^{[2
]}

Nisikawa, Osamu ^{[1
]}

Arishima, Kazuyoshi ^{[1
]}

机构：

[1] Azabu Univ, Sch Vet Med, Dept Anat 2, Kanagawa 2298501, Japan

[2] Azabu Univ, Sch Vet Med, Dept Vet Pharmacol, Kanagawa 2298501, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2009年 / 71卷 / 03期

关键词：

DES; epididymis; rat; ESTROGEN-RECEPTOR-BETA; DUAL 5-ALPHA-REDUCTASE INHIBITOR; NEONATAL TREATMENT; ER-BETA; REPRODUCTIVE-TRACT; VAS-DEFERENS; EXPRESSION; ANDROGEN; PROSTATE; IMMUNOEXPRESSION;

D O I：

10.1292/jvms.71.375

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In our previous Study, prenatal diethylstilbestrol (DES) exposure (days 7-21 of gestation) suppressed plasma testosterone levels and histological development in the epididymis of rat Offspring. In this study, we measured cell proliferation in epididymal ducutules and the expression of steroid hormone receptors and 5 alpha-reductase 1 in the epididymis to assess the effect of DES on epididymal development in the off spring. Prenatal DES exposure did not alter the cell division index, but Suppressed the expression of androgen receptor mRNA at 15 weeks after birth, and stimulated estrogen receptor a mRNA at 6 weeks. These results Suggest that prenatal DES exposure results in the retardation of epididymal tissue maturation by disruption of the postnatal expression of steroid hormone receptors.

引用

页码：375 / 378

页数：4

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