Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults

被引：26

作者：

Lee, Yu-Lin ^{[1
,2
,3
]}

Liu, Chun-Eng ^{[1
]}

Cho, Wen-Long ^{[3
]}

Kuo, Chen-Ling ^{[2
]}

Cheng, Wen-Ling ^{[2
]}

Huang, Ching-Shan ^{[2
]}

Liu, Chin-San ^{[2
,4
,5
]}

机构：

[1] Changhua Christian Hosp, Dept Internal Med, Div Infect Dis, Changhua 500, Taiwan

[2] Changhua Christian Hosp, Vasc & Genom Ctr, Changhua 500, Taiwan

[3] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[4] Changhua Christian Hosp, Dept Neurol, Changhua 500, Taiwan

[5] China Med Univ Hosp, Grad Inst Integrat Chinese & Western Med, Taichung, Taiwan

来源：

BIOMARKERS | 2014年 / 19卷 / 02期

关键词：

Atherosclerosis; cytomegalovirus; intima media thickness; mitochondrial dysfunction; oxidative stress; INTIMA-MEDIA THICKNESS; HERPES-SIMPLEX-VIRUS; CHLAMYDIA-PNEUMONIAE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; OXIDIZED LDL; INFECTION; RISK; AUTOANTIBODIES; PATHOGENESIS;

D O I：

10.3109/1354750X.2013.877967

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis. Methods: Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNADCT) and intima media thickness (IMT). Results: The CMV DNA positive subjects had a higher mean mtDNADCT and greater IMT than subjects in the control group. Conclusions: Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.

引用

页码：109 / 113

页数：5

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