Parenterally Administered Porcine Epidemic Diarrhea Virus-Like Particle-Based Vaccine Formulated with CCL25/28 Chemokines Induces Systemic and Mucosal Immune Protectivity in Pigs
被引:20
作者:
Hsu, Chin-Wei
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机构:
Natl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, TaiwanNatl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Hsu, Chin-Wei
[1
]
Chang, Ming-Hao
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机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Taoyuan 320, TaiwanNatl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Chang, Ming-Hao
[2
]
Chang, Hui-Wen
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机构:
Natl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, TaiwanNatl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Chang, Hui-Wen
[1
]
Wu, Tzong-Yuan
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机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Taoyuan 320, Taiwan
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 406, TaiwanNatl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Wu, Tzong-Yuan
[2
,3
]
Chang, Yen-Chen
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机构:
Natl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, TaiwanNatl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Chang, Yen-Chen
[1
]
机构:
[1] Natl Taiwan Univ, Sch Vet Med, Grad Inst Mol & Comparat Pathobiol, Taipei 106, Taiwan
Generation of a safe, economical, and effective vaccine capable of inducing mucosal immunity is critical for the development of vaccines against enteric viral diseases. In the current study, virus-like particles (VLPs) containing the spike (S), membrane (M), and envelope (E) structural proteins of porcine epidemic diarrhea virus (PEDV) expressed by the novel polycistronic baculovirus expression vector were generated. The immunogenicity and protective efficacy of the PEDV VLPs formulated with or without mucosal adjuvants of CCL25 and CCL28 (CCL25/28) were evaluated in post-weaning pigs. While pigs intramuscularly immunized with VLPs alone were capable of eliciting systemic anti-PEDV S-specific IgG and cellular immunity, co-administration of PEDV VLPs with CCL25/28 could further modulate the immune responses by enhancing systemic anti-PEDV S-specific IgG, mucosal IgA, and cellular immunity. Upon challenge with PEDV, both VLP-immunized groups showed milder clinical signs with reduced fecal viral shedding as compared to the control group. Furthermore, pigs immunized with VLPs adjuvanted with CCL25/28 showed superior immune protection against PEDV. Our results suggest that VLPs formulated with CCL25/28 may serve as a potential PEDV vaccine candidate and the same strategy may serve as a platform for the development of other enteric viral vaccines.
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Langel, Stephanie N.
;
Paim, Francine Chimelo
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Paim, Francine Chimelo
;
Lager, Kelly M.
论文数: 0引用数: 0
h-index: 0
机构:
ARS, Virus & Prion Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA 50010 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Lager, Kelly M.
;
Vlasova, Anastasia N.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Vlasova, Anastasia N.
;
Saif, Linda J.
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h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
Li, Wentao
;
van Kuppeveld, Frank J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
van Kuppeveld, Frank J. M.
;
He, Qigai
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Hubei Province, Peoples R ChinaUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
He, Qigai
;
Rottier, Peter J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
Rottier, Peter J. M.
;
Bosch, Berend-Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Li, Wentao
;
Li, Heng
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机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Li, Heng
;
Liu, Yunbo
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机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Liu, Yunbo
;
Pan, Yongfei
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Wens Foodstuffs Grp Co Ltd, Xinxing, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Pan, Yongfei
;
Deng, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Deng, Feng
;
Song, Yanhua
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Wens Foodstuffs Grp Co Ltd, Xinxing, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Song, Yanhua
;
Tang, Xibiao
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h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Tang, Xibiao
;
He, Qigai
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h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Lin, Chun-Ming
;
Gao, Xiang
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机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Gao, Xiang
;
Oka, Tomoichiro
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Oka, Tomoichiro
;
Vlasova, Anastasia N.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Vlasova, Anastasia N.
;
Esseili, Malak A.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Esseili, Malak A.
;
Wang, Qiuhong
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Wang, Qiuhong
;
Saif, Linda J.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Chungli, Taiwan
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, TaiwanChung Yuan Christian Univ, Dept Biosci Technol, Chungli, Taiwan
机构:
Hosp Special Surg, Div Res, New York, NY 10021 USA
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Publ Hlth, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA
Ma, Yan
;
Mazumdar, Madhu
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Publ Hlth, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA
Mazumdar, Madhu
;
Memtsoudis, Stavros G.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Anesthesiol, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Langel, Stephanie N.
;
Paim, Francine Chimelo
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Paim, Francine Chimelo
;
Lager, Kelly M.
论文数: 0引用数: 0
h-index: 0
机构:
ARS, Virus & Prion Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA 50010 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Lager, Kelly M.
;
Vlasova, Anastasia N.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Vlasova, Anastasia N.
;
Saif, Linda J.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
Li, Wentao
;
van Kuppeveld, Frank J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
van Kuppeveld, Frank J. M.
;
He, Qigai
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Hubei Province, Peoples R ChinaUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
He, Qigai
;
Rottier, Peter J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
Rottier, Peter J. M.
;
Bosch, Berend-Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Li, Wentao
;
Li, Heng
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Li, Heng
;
Liu, Yunbo
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Liu, Yunbo
;
Pan, Yongfei
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Wens Foodstuffs Grp Co Ltd, Xinxing, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Pan, Yongfei
;
Deng, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Deng, Feng
;
Song, Yanhua
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Wens Foodstuffs Grp Co Ltd, Xinxing, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Song, Yanhua
;
Tang, Xibiao
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
Tang, Xibiao
;
He, Qigai
论文数: 0引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R ChinaHuazhong Agr Univ, State Key Lab Agr Microbiol, Coll Vet Med, Wuhan 430070, Peoples R China
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Lin, Chun-Ming
;
Gao, Xiang
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Gao, Xiang
;
Oka, Tomoichiro
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Oka, Tomoichiro
;
Vlasova, Anastasia N.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Vlasova, Anastasia N.
;
Esseili, Malak A.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Esseili, Malak A.
;
Wang, Qiuhong
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
Wang, Qiuhong
;
Saif, Linda J.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Coll Food Agr & Environm Sci, Food Anim Hlth Res Program,Dept Vet Prevent Med, Wooster, OH 44691 USA
机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Chungli, Taiwan
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, TaiwanChung Yuan Christian Univ, Dept Biosci Technol, Chungli, Taiwan
机构:
Hosp Special Surg, Div Res, New York, NY 10021 USA
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Publ Hlth, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA
Ma, Yan
;
Mazumdar, Madhu
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Publ Hlth, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA
Mazumdar, Madhu
;
Memtsoudis, Stavros G.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Anesthesiol, New York, NY 10021 USAHosp Special Surg, Div Res, New York, NY 10021 USA