New insights into the multidimensional concept of macrophage ontogeny, activation and function

被引：586
作者：
Ginhoux, Florent [1 ]
Schultze, Joachim L. [2 ,3 ]
Murray, Peter J. [4 ,5 ]
Ochando, Jordi [6 ,7 ]
Biswas, Subhra K. [1 ]
机构：
[1] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore
[2] Univ Bonn, LIMES Life & Med Sci Inst, Genom & Immunoregulat, Bonn, Germany
[3] German Ctr Neurodegenerat Dis, Bonn, Germany
[4] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[5] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[6] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA
[7] Inst Salud Carlos III, Ctr Nacl Microbiol, Immunol Trasplantes, Madrid, Spain
来源：
NATURE IMMUNOLOGY | 2016年 / 17卷 / 01期
关键词：
TUMOR-ASSOCIATED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; CELL RNA-SEQ; INFLAMMATORY MONOCYTES; ALVEOLAR MACROPHAGES; FETAL MONOCYTES; GENE-EXPRESSION; ANTIINFLAMMATORY PROPERTIES; ANALYSIS REVEALS; DENDRITIC CELLS;
D O I：
10.1038/ni.3324
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed unknown aspects of their development and function. Following development, macrophages are activated by diverse signals. Such tissue microenvironmental signals together with epigenetic changes influence macrophage development, activation and functional diversity, with consequences in disease and homeostasis. We discuss here how recent discoveries in these areas have led to a multidimensional concept of macrophage ontogeny, activation and function. In connection with this, we also discuss how technical advances facilitate a new roadmap for the isolation and analysis of macrophages at high resolution.
引用
收藏
页码：34 / 40
页数：7
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