Solubility of Bioactive Compound Hesperidin in Six Pure Solvents at (298.15 to 333.15) K

被引:71
作者
Anwer, Md Khalid [1 ]
Al-Shdefat, Ramadan [1 ]
Jamil, Shahid [1 ]
Alam, Prawez [2 ]
Abdel-Kader, Maged S. [2 ]
Shakeel, Faiyaz [3 ]
机构
[1] Salman Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
[2] Salman Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj, Saudi Arabia
[3] King Saud Univ, CEBR, Riyadh 11451, Saudi Arabia
关键词
WATER COSOLVENT MIXTURES; MAGNESIUM-DL-ASPARTATE; EX-VIVO PERMEATION; P-TOLUIC ACID; GREEN SOLVENTS; THERMODYNAMICS; PREDICTION;
D O I
10.1021/je500206w
中图分类号
O414.1 [热力学];
学科分类号
摘要
Temperature-dependent solubility data of bioactive compound hesperidin has not been reported in any solvent in the literature so far. Therefore, the aim of the current study was to measure the solubility of bioactive compound hesperidin in six different pure solvents namely water, ethanol, isopropyl alcohol (IPA), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), and 1-butanol from (298.15 to 333.15) K using the shake flask method. The experimental solubilities of hesperidin were regressed by Apelblat equation with root-mean-square deviations in the range of 6.32.10(-7) to 0.184 in all solvents investigated. The correlation coefficients in pure solvents were observed in the range of 0.995 to 0.999. The mole fraction solubility of hesperidin was found to be higher in PEG-400 (6.33.10(-3) at 298.15 K) and PG (5.35.10(-4) at 298.15 K) as compared to water (1.47.10(-7) at 298.15 K), ethanol (3.45.10(-5) at 298.15 K), IPA (1.53.10(-5) at 298.15 K), and 1-butanol (3.15.10(-4) at 298.15 K). The data of the current study could be useful in crystallization/purification and formulation development of hesperidin in the chemical/pharmaceutical industry.
引用
收藏
页码:2065 / 2069
页数:5
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