Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

被引：32
作者：
Kikuchi, Luciana [1 ]
Oliveira, Claudia P. [1 ]
Carrilho, Flair J. [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Inst Canc Estado Sao Paulo, Sao Paulo Clin Liver Canc Grp,Hosp Clin,Dept Gast, BR-05403000 Sao Paulo, Brazil
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
关键词：
NATURAL-HISTORY; DIABETES INCREASES; RISK-FACTORS; STEATOHEPATITIS; CIRRHOSIS; OBESITY; CANCER; COHORT; GENE; MICE;
D O I：
10.1155/2014/106247
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hepatocellular carcinoma (HCC) incidence is increasing worldwide in recent years. Most HCC cases develop in the presence of advanced chronic liver disease related to chronic hepatitis C virus (HCV) infection, chronic hepatitis B (HBV) infection, and alcohol abuse. Approximately 15-50% of HCC cases are classified as idiopathic, suggesting that other risk factors are responsible for its rising incidence. Recent studies suggest that nonalcoholic fatty liver disease (NAFLD) can be associated with these "idiopathic" cases. NAFLD progresses slowly and can develop into liver cirrhosis, liver failure, and HCC. In the last few years, NAFLD has received more attention because of its high prevalence worldwide.
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