PHYSICAL EXERCISE TRAINING AND NEUROVASCULAR UNIT IN ISCHEMIC STROKE

被引：27

作者：

Wang, X. ^{[1
]}

Zhang, M. ^{[2
]}

Feng, R. ^{[1
]}

Li, W. -B. ^{[2
]}

Ren, S. -Q. ^{[1
]}

Zhang, J. ^{[3
]}

Zhang, F. ^{[3
,4
]}

机构：

[1] Hebei Med Univ, Hosp 3, Dept Neurol, Shijiazhuang 050051, Hebei, Peoples R China

[2] Hebei Med Univ, Dept Pathophysiol, Shijiazhuang 050017, Peoples R China

[3] Hebei Med Univ, Hosp 3, Dept Rehabil Med, Shijiazhuang 050051, Hebei, Peoples R China

[4] Hebei Med Univ, Hosp 3, Hebei Prov Orthoped Biomech Key Lab, Shijiazhuang 050051, Hebei, Peoples R China

来源：

NEUROSCIENCE | 2014年 / 271卷

基金：

中国国家自然科学基金;

关键词：

neurovascular unit (NVU); stroke; angiogenesis; blood-brain barrier (BBB); cerebral blood vessels; BLOOD-BRAIN-BARRIER; TRANSIENT CEREBRAL-ISCHEMIA; ACTIVATED PROTEIN-KINASE; TREADMILL EXERCISE; RAT MODEL; VOLUNTARY EXERCISE; EXPRESSION; INJURY; PERICYTES; DAMAGE;

D O I：

10.1016/j.neuroscience.2014.04.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physical exercise could exert a neuroprotective effect in both clinical studies and animal experiments. A series of related studies have indicated that physical exercise could reduce infarct volume, alleviate neurological deficits, decrease blood-brain barrier dysfunction, promote angiogenesis in cerebral vascular system and increase the survival rate after ischemic stroke. In this review, we summarized the protective effects of physical exercise on neurovascular unit (NVU), including neurons, astrocytes, pericytes and the extracellular matrix. Furthermore, it was demonstrated that exercise training could decrease the blood-brain barrier dysfunction and promote angiogenesis in cerebral vascular system. An awareness of the exercise intervention benefits pre- and post stroke may lead more stroke patients and people with high-risk factors to accept exercise therapy for the prevention and treatment of stroke. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：99 / 107

页数：9

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