New imidazo[1,2-a]quinoxaline derivatives: Synthesis and in vitro activity against human melanoma

被引：41

作者：

Deleuze-Masquefa, Carine ^{[1
]}

Moarbess, Georges ^{[1
]}

Khier, Sonia ^{[2
]}

David, Nadege ^{[1
]}

Gayraud-Paniagua, Stephanie ^{[1
]}

Bressolle, Francoise ^{[2
,3
]}

Pinguet, Frederic ^{[3
]}

Bonnet, Pierre-Antoine ^{[1
]}

机构：

[1] Univ Montpellier 1, Fac Pharm, Lab Chim Biomol & Environm, EA 4215, F-34093 Montpellier 5, France

[2] Univ Montpellier 1, Fac Pharm, Pharmacocinet Clin, F-34093 Montpellier, France

[3] Ctr Reg Lutte Canc, F-34000 Montpellier, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

Imidazoquinoxalines; Imiquimod; Melanoma; In vitro activity; MALIGNANT-MELANOMA; IMIQUIMOD; FOTEMUSTINE; INTERFERON; INHIBITOR; GROWTH; KINASE; FAMILY; MICE;

D O I：

10.1016/j.ejmech.2009.02.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New imidazo[1,2-a] quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho-fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-coupling reaction using microwave assistance. Antitumor activities of these derivatives were evaluated by growth inhibition of A375 cells in vitro. All compounds exhibited high activities compared to imiquimod and fotemustine used as references. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3406 / 3411

页数：6

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