Copper-Catalyzed N-H/C-H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-Fused Tetrahydrocyclopenta[b]indoles

被引：18

作者：

Liu, Tong-Xin ^{[1
]}

Wei, Juan ^{[1
]}

Zhang, Pengling ^{[1
]}

Ru, Yifei ^{[1
]}

Ma, Jinliang ^{[1
]}

Zhang, Xingjie ^{[1
]}

Ma, Nana ^{[1
]}

Zhang, Guisheng ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henan Key Lab Organ Funct Mol & Drug Innovat, Key Lab Green Chem Media & React,Minist Educ,Sch, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 16期

关键词：

TRANSITION-METAL-FREE; 1,3-DIPOLAR CYCLOADDITION; FULLERENE CHEMISTRY; ONE-POT; DERIVATIVES; ANNULATION; C-60; FUNCTIONALIZATION; HETEROANNULATION; HYDROFULLERENES;

D O I：

10.1021/acs.orglett.9b02354

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reported herein is a new copper-catalyzed N-H/C-H sequential relay oxidative radical carboannulation of [60]fullerene with C2-functionalized free indoles for the direct construction of novel [60]fullerene-fused tetrahydrocyclopenta[b]indoles. The transformation shows high regioselectivity and atom economy, broad substrate scope, and good functional group tolerance, providing an efficient and practical approach to access diversely substituted fullerene-fused polycyclic derivatives from simple hydrocarbons.

引用

页码：6461 / 6465

页数：5

共 87 条

[1] Novel C60-based building blocks derived from C602- anion [J].