Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin-induced diabetic nephropathy rats

被引：5
作者：
Ambalavanan, Ragavee [1 ]
John, Arul Daniel [1 ]
Selvaraj, Asha Devi [1 ]
机构：
[1] Vellore Inst Technol, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India
来源：
IET NANOBIOTECHNOLOGY | 2021年 / 15卷 / 04期
关键词：
MELLITUS; FIBROSIS;
D O I：
10.1049/nbt2.12030
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC-loaded PLA Nanoparticles (TC-PLA NPs) on streptozotocin (STZ)-induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC-PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.
引用
收藏
页码：411 / 417
页数：7
相关论文
共 27 条
[1]   Nano-encapsulated Tinospora cordifolia (Willd.) using poly (D, L-lactide) nanoparticles educe effective control in streptozotocin-induced type 2 diabetic rats [J].
Ambalavanan, Ragavee ;
John, Arul Daniel ;
Selvaraj, Asha Devi .
IET NANOBIOTECHNOLOGY, 2020, 14 (09) :803-808
[2]   A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering [J].
Burton, Todd P. ;
Callanan, Anthony .
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018, 15 (03) :301-310
[3]  
Chen Z.J., 2018, COMPLEMENT ALTERN ME, P1
[4]   Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocin-induced diabetic rats [J].
Clark, TA ;
Heyliger, CE ;
Edel, AL ;
Goel, DP ;
Pierce, GN .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (09) :1145-1151
[5]  
Cohen MP, 1996, DIABETOLOGIA, V39, P270
[6]   Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease [J].
Hu, Fang ;
Xue, Meng ;
Li, Yang ;
Jia, Yi-Jie ;
Zheng, Zong-Ji ;
Yang, Yan-Lin ;
Guan, Mei-Ping ;
Sun, Liao ;
Xue, Yao-Ming .
JOURNAL OF DIABETES RESEARCH, 2018, 2018
[7]   TINOSPORA CORDIFOLIA: A PHYTOPHARMACOLOGICAL REVIEW [J].
Joshi, Garish ;
Kaur, Rajandeep .
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (03) :890-897
[8]   Diabetes mellitus: The epidemic of the century [J].
Kharroubi, Akram T. ;
Darwish, Hisham M. .
WORLD JOURNAL OF DIABETES, 2015, 6 (06) :850-867
[9]  
Lai KN, 2011, CONTRIB NEPHROL, V170, P1
[10]  
Mahendran KB, 2016, INT J HEALTH SCI-IJH, V10, P492
123