EML4-ALK: Honing In on a New Target in Non-Small-Cell Lung Cancer

被引：250
作者：
Horn, Leora [1 ]
Pao, William [1 ]
机构：
[1] Vanderbilt Ingram Canc Ctr, Nashville, TN USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2009年 / 27卷 / 26期
关键词：
GROWTH-FACTOR RECEPTOR; ACTIVATING MUTATIONS; FUSION GENE; ALK KINASE; KRAS MUTATIONS; NEVER SMOKERS; PHASE-III; NPM-ALK; GEFITINIB; IDENTIFICATION;
D O I：
10.1200/JCO.2009.23.6661
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：4232 / 4235
页数：4
相关论文
共 50 条
  • [11] The prevalence of EML4-ALK variants in patients with non-small-cell lung cancer: a systematic review and meta-analysis
    He, Yuan
    Sun, Li-Yue
    Gong, Rui
    Liu, Qing
    Long, Ya-Kang
    Liu, Fang
    Wang, Fang
    BIOMARKERS IN MEDICINE, 2019, 13 (12) : 1035 - 1045
  • [12] EML4-ALK biology and drug resistance in non-small cell lung cancer: a new phase of discoveries
    Elshatlawy, Mariam
    Sampson, Josephina
    Clarke, Katy
    Bayliss, Richard
    MOLECULAR ONCOLOGY, 2023, 17 (06) : 950 - 963
  • [13] Non-small Cell Lung Cancer Patients with EML4-ALK Fusion Gene Are Insensitive to Cytotoxic Chemotherapy
    Morodomi, Yosuke
    Takenoyama, Mitsuhiro
    Inamasu, Eiko
    Toyozawa, Ryo
    Kojo, Miyako
    Toyokawa, Gouji
    Shiraishi, Yoshimasa
    Takenaka, Tomoyoshi
    Hirai, Fumihiko
    Yamaguchi, Masafumi
    Taguchi, Kenichi
    Seto, Takashi
    Sugio, Kenji
    Ichinose, Yukito
    ANTICANCER RESEARCH, 2014, 34 (07) : 3825 - 3830
  • [14] EML4-ALK translocation is associated with early onset of disease and other clinicopathological features in Chinese female never-smokers with non-small-cell lung cancer
    Ren, Weihong
    Zhang, Bo
    Ma, Jie
    Li, Wencai
    Lan, Jianyun
    Men, Hui
    Zhang, Qinxian
    ONCOLOGY LETTERS, 2015, 10 (06) : 3385 - 3392
  • [15] EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
    Choi, Young Lim
    Soda, Manabu
    Yamashita, Yoshihiro
    Ueno, Toshihide
    Takashima, Junpei
    Nakajima, Takahiro
    Yatabe, Yasushi
    Takeuchi, Kengo
    Hamada, Toru
    Haruta, Hidenori
    Ishikawa, Yuichi
    Kimura, Hideki
    Mitsudomi, Tetsuya
    Tanio, Yoshiro
    Mano, Hiroyuki
    NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) : 1734 - 1739
  • [16] EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations
    Thunnissen, Erik
    Bubendorf, Lukas
    Dietel, Manfred
    Elmberger, Goran
    Kerr, Keith
    Lopez-Rios, Fernando
    Moch, Holger
    Olszewski, Wlodzimierz
    Pauwels, Patrick
    Penault-Llorca, Frederique
    Rossi, Giulio
    VIRCHOWS ARCHIV, 2012, 461 (03) : 245 - 257
  • [17] EML4-ALK Rearrangement and Its Clinical Significance in Chinese Patients with Advanced Non-Small Cell Lung Cancer
    Wang, Zhijie
    Zhang, Xuchao
    Bai, Hua
    Zhao, Jun
    Zhuo, Minglei
    An, Tongtong
    Duan, Jianchun
    Yang, Lu
    Wu, Meina
    Wang, Shuhang
    Wang, Yuyan
    Wu, Yilong
    Wang, Jie
    ONCOLOGY, 2012, 83 (05) : 248 - 256
  • [18] Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells
    Wang, Rui
    Deng, Xiaolan
    Yoshioka, Yuichiro
    Vougiouklakis, Theodore
    Park, Jae-Hyun
    Suzuki, Takehiro
    Dohmae, Naoshi
    Ueda, Koji
    Hamamoto, Ryuji
    Nakamura, Yusuke
    CANCER SCIENCE, 2017, 108 (06) : 1203 - 1209
  • [19] Response to crizotinib in a non-small-cell lung cancer patient harboring an EML4-ALK fusion with an atypical LTBP1 insertion
    Aguado, Cristina
    Gil, Maria-de-los-Llanos
    Yeste, Zaira
    Gimenez-Capitan, Ana
    Teixido, Cristina
    Karachaliou, Niki
    Viteri, Santiago
    Rosell, Rafael
    Molina-Vila, Miguel A.
    ONCOTARGETS AND THERAPY, 2018, 11 : 1117 - 1120
  • [20] Detection of EML4-ALK fusion genes in non-small cell lung cancer patients with clinical features associated with EGFR mutations
    Zhou Shaozhang
    Lin Xiaomei
    Zeng Aiping
    He Jianbo
    Song Xiangqun
    Yu Qitao
    GENES CHROMOSOMES & CANCER, 2012, 51 (10) : 925 - 932
12345