Subtype-specific reduction of olfactory bulb interneurons in Pax6 heterozygous mutant mice

被引：27
|
作者：
Haba, Hasumi [1 ]
Nomura, Tadashi [2 ]
Suto, Fumikazu [1 ]
Osumi, Noriko [1 ,3 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Anim Res, Div Dev Neurosci,Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
[3] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan
来源：
NEUROSCIENCE RESEARCH | 2009年 / 65卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
Olfactory bulb; Interneurons; External plexiform layer; Calretinin; Parvalbumin; Pax6; EXTERNAL PLEXIFORM LAYER; GLOMERULAR LAYER; PERIGLOMERULAR CELLS; STEM-CELLS; NEURONS; SYSTEM; EYE; SUBPOPULATIONS; HETEROGENEITY; NEUROGENESIS;
D O I：
10.1016/j.neures.2009.05.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interneurons in the olfactory bulb (OB) play essential roles in the processing of olfactory information. They are classified into several subpopulations by the expression of different neurochemical markers. Here we focused on a transcription factor Pax6, and examined its expression and function in distinct subtypes of OB interneurons. We identified Pax6 expression in specific subtypes of interneurons in the external plexiform layer(EPL). The number of these interneuron subtypes was dramatically decreased in Pax6 heterozygous mutant mice. These results indicate that Pax6 is required for differentiation and/or maintenance of EPL interneurons in the adult mouse OB. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：116 / 121
页数：6
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