The role and therapeutic implications of PI3K signaling pathway in cancer

被引:8
作者
Leiphrakpam, Premila D. [1 ]
Chowdhury, Sanjib [1 ]
Wang, Jing [2 ]
Black, Jennifer D. [3 ]
Are, Chandrakanth [4 ]
机构
[1] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Omaha, NE USA
[2] Ohio State Univ, Coll Med, Dept Canc Biol & Genet, Columbus, OH 43210 USA
[3] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE USA
[4] Univ Nebraska Med Ctr, Div Surg Oncol, Dept Surg, Coll Med, Omaha, NE 68198 USA
关键词
BREAST; MECHANISMS; EXPRESSION;
D O I
10.1002/jso.26296
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:39 / 41
页数:3
相关论文
共 21 条
[1]   Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer [J].
Andre, Fabrice ;
Ciruelos, Eva ;
Rubovszky, Gabor ;
Campone, Mario ;
Loibl, Sibylle ;
Rugo, Hope S. ;
Iwata, Hiroji ;
Conte, Pierfranco ;
Mayer, Ingrid A. ;
Kaufman, Bella ;
Yamashita, Toshinari ;
Lu, Yen-Shen ;
Inoue, Kenichi ;
Takahashi, Masato ;
Papai, Zsuzsanna ;
Longin, Anne-Sophie ;
Mills, David ;
Wilke, Celine ;
Hirawat, Samit ;
Juric, Dejan .
NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (20) :1929-1940
[2]   The crosstalk between long non-coding RNAs and PI3K in cancer [J].
Benetatos, Leonidas ;
Voulgaris, Evangelos ;
Vartholomatos, Georgios .
MEDICAL ONCOLOGY, 2017, 34 (03)
[3]   PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer [J].
Bosch, Ana ;
Li, Zhiqiang ;
Bergamaschi, Anna ;
Ellis, Haley ;
Toska, Eneda ;
Prat, Aleix ;
Tao, Jessica J. ;
Spratt, Daniel E. ;
Viola-Villegas, Nerissa T. ;
Castel, Pau ;
Minuesa, Gerard ;
Morse, Natasha ;
Rodon, Jordi ;
Ibrahim, Yasir ;
Cortes, Javier ;
Perez-Garcia, Jose ;
Galvan, Patricia ;
Grueso, Judit ;
Guzman, Marta ;
Katzenellenbogen, John A. ;
Kharas, Michael ;
Lewis, Jason S. ;
Dickler, Maura ;
Serra, Violeta ;
Rosen, Neal ;
Chandarlapaty, Sarat ;
Scaltriti, Maurizio ;
Baselga, Jose .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (283)
[4]   Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer [J].
Carver, Brett S. ;
Chapinski, Caren ;
Wongvipat, John ;
Hieronymus, Haley ;
Chen, Yu ;
Chandarlapaty, Sarat ;
Arora, Vivek K. ;
Le, Carl ;
Koutcher, Jason ;
Scher, Howard ;
Scardino, Peter T. ;
Rosen, Neal ;
Sawyers, Charles L. .
CANCER CELL, 2011, 19 (05) :575-586
[5]   Targeting the PI3K pathway in cancer: are we making headway? [J].
Janku, Filip ;
Yap, Timothy A. ;
Meric-Bernstam, Funda .
NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (05) :273-291
[6]  
Jun T, 1999, Sci STKE, V1999, pPE1, DOI 10.1126/stke.1999.13.pe1
[7]   Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer [J].
Leiphrakpam, Premila D. ;
Lazenby, Audrey J. ;
Chowdhury, Sanjib ;
Smith, Lynette M. ;
Mathiesen, Michelle ;
Brattain, Michael G. ;
Wang, Jing ;
Black, Jennifer D. ;
Are, Chandrakanth .
JOURNAL OF SURGICAL ONCOLOGY, 2020, 121 (03) :547-560
[8]   Ezrin expression and cell survival regulation in colorectal cancer [J].
Leiphrakpam, Premila D. ;
Rajput, Ashwani ;
Mathiesen, Michelle ;
Agarwal, Ekta ;
Lazenby, Audrey J. ;
Are, Chandrakanth ;
Brattain, Michael G. ;
Chowdhury, Sanjib .
CELLULAR SIGNALLING, 2014, 26 (05) :868-879
[9]   Targeting the phosphoinositide 3-kinase pathway in cancer [J].
Liu, Pixu ;
Cheng, Hailing ;
Roberts, Thomas M. ;
Zhao, Jean J. .
NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (08) :627-644
[10]   Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE) [J].
Loibl, Sibylle ;
de la Pena, Lorena ;
Nekljudova, Valentina ;
Zardavas, Dimitrios ;
Michiels, Stefan ;
Denkert, Carsten ;
Rezai, Mahdi ;
Bermejo, Begona ;
Untch, Michael ;
Lee, Soo Chin ;
Turri, Sabine ;
Urban, Patrick ;
Kuemmel, Sherko ;
Steger, Guenther ;
Gombos, Andrea ;
Lux, Michael ;
Piccart, Martine J. ;
Von Minckwitz, Gunter ;
Baselga, Jose ;
Loi, Sherene .
EUROPEAN JOURNAL OF CANCER, 2017, 85 :133-145