Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

被引：38
作者：
Wang, Hung-Li [1 ]
Yeh, Hsin [1 ]
Li, Bin-Han [2 ]
Lin, Chia-Her [3 ]
Hsiao, Ta-Chih [4 ]
Tsai, De-Hao [1 ]
机构：
[1] NTHU, Dept Chem Engn, Hsinchu 30013, Taiwan
[2] NTHU, Dept Chem, Hsinchu 30013, Taiwan
[3] Chung Yuan Christian Univ, Dept Chem, Taoyuan 32023, Taiwan
[4] Natl Taiwan Univ, Grad Inst Environm Engn, Taipei 10673, Taiwan
来源：
ACS APPLIED NANO MATERIALS | 2019年 / 2卷 / 06期
关键词：
metal-organic framework; drug; release; aerosol; colloid; DRUG-DELIVERY; ADSORPTION; MOLECULES; PLATFORM; UIO-66;
D O I：
10.1021/acsanm.9b00834
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (approximate to 55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.
引用
收藏
页码：3329 / 3334
页数：11
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