Manifold-enhanced Segmentation through Random Walks on Linear Subspace Priors

In this paper we propose a novel method for knowledge-based segmentation. Our contribution lies on the introduction of linear sub-spaces constraints within the random-walk segmentation framework. Prior knowledge is obtained through principal component analysis that is then combined with conventional boundary constraints for image segmentation. The approach is validated on a challenging clinical setting that is multicomponent segmentation of the human upper leg skeletal muscle in Magnetic Resonance Imaging, where there is limited visual differentiation support between muscle classes.