An overview of the molecular mechanisms of mitophagy in yeast

被引:6
作者
Schuster, Ramona [1 ]
Okamoto, Koji [1 ]
机构
[1] Osaka Univ, Grad Sch Frontier Biosci, Lab Mitochondrial Dynam, 1-3 Yamadaoka, Suita, Osaka 5650871, Japan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2022年 / 1866卷 / 11期
关键词
Mitochondria; Autophagy; Yeast; Atg32; Atg11; Atg8; PHOSPHATIDYLINOSITOL KINASE HOMOLOG; WD-REPEAT PROTEIN; SELECTIVE AUTOPHAGY; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL FISSION; SCAFFOLD PROTEIN; STRESS-RESPONSE; MEMBRANE-BINDING; TAGS PEROXISOMES; SUPEROXIDE ANION;
D O I
10.1016/j.bbagen.2022.130203
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy-dependent selective degradation of excess or damaged mitochondria, termed mitophagy, is a tightly regulated process necessary for mitochondrial quality and quantity control. Mitochondria are highly dynamic and major sites for vital cellular processes such as ATP and iron-sulfur cluster biogenesis. Due to their pivotal roles for immunity, apoptosis, and aging, the maintenance of mitochondrial function is of utmost importance for cellular homeostasis. In yeast, mitophagy is mediated by the receptor protein Atg32 that is localized to the outer mitochondrial membrane. Upon mitophagy induction, Atg32 expression is transcriptionally upregulated, which leads to its accumulation on the mitochondrial surface and to recruitment of the autophagic machinery via its direct interaction with Atg11 and Atg8. Importantly, post-translational modifications such as phosphorylation further fine-tune the mitophagic response. This review summarizes the current knowledge about mitophagy in yeast and its connection with mitochondrial dynamics and the ubiquitin-proteasome system.
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页数:9
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