A colorimetric sensing ensemble for heparin

被引：214

作者：

Zhong, ZL ^{[1
]}

Anslyn, EV ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 31期

关键词：

D O I：

10.1021/ja020505k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A receptor possessing ammoniums and a novel amino acid with a boronic acid side chain was designed and synthesized. The receptor shows good affinity and selectivity for heparin over similar polysaccharides possessing lower anionic charge density. The affinity for heparin is similar to that for a heparin disaccharide, indicating that disaccharidic units are the likely sites for binding to the receptor. The receptor has a potential use for creating a colorimetric assay for heparin. Copyright © 2002 American Chemical Society.

引用

页码：9014 / 9015

页数：2

共 45 条

[1] Achieving large color changes in response to the presence of amino acids:: A molecular sensing ensemble with selectivity for aspartate [J].