Potentiation of osteoclastogenesis by adipogenic conversion of bone marrow-derived mesenchymal stem cells

被引：8

作者：

Mori, Keisuke ^{[1
]}

Suzuki, Keiji ^{[1
]}

Hozumi, Akira ^{[2
]}

Goto, Hisataka ^{[2
]}

Tomita, Masato ^{[2
]}

Koseki, Hironobu ^{[2
]}

Yamashita, Shunichi ^{[1
]}

Osaki, Makoto ^{[2
]}

机构：

[1] Nagasaki Univ, Atom Bomb Dis Inst, Dept Radiat Med Sci, Nagasaki 8528523, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Orthopaed Surg, Nagasaki 8528501, Japan

来源：

BIOMEDICAL RESEARCH-TOKYO | 2014年 / 35卷 / 02期

关键词：

MOLECULAR-MECHANISMS; DIFFERENTIATION; OSTEOPOROSIS; RANKL; INSIGHTS; FAT; RESORPTION; OBESITY; DISEASE;

D O I：

10.2220/biomedres.35.153

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bone marrow-derived mesenchymal stem cells (BMSCs) are the indispensable component of the bone marrow, being the common precursors for adipocytes and osteoblasts. We show here that adipogenic differentiation resulted in increase in the production of adipocyte markers, such as adiponectin, fatty-acid binding proteins (FABP4), peroxisome proliferator-activated receptor gamma (PPAR gamma), as well as the receptor activator of nuclear-kappa B ligand (RANKL). Co-culture of osteoclast precursors (0CPs) with BMSCs-derived adipocytes significantly enhanced osteoclast differentiation with low-dose RANKL, whose levels alone could not promote osteoclastogenesis. These results demonstrate for the first time that adipogenic differentiation of BMSCs plays a pivotal role in maintaining bone homeostasis.

引用

页码：153 / 159

页数：7

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