An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

被引：44

作者：

Dong, Baoli ^{[1
]}

Song, Wenhui ^{[1
]}

Lu, Yaru ^{[1
]}

Kong, Xiuqi ^{[1
]}

Mehmood, Abdul Hadi ^{[1
]}

Lin, Weiying ^{[1
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Inst Fluorescent Probes Biol Imaging, Sch Mat Sci & Engn, Jinan 250022, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 72期

关键词：

INTRACELLULAR PH; QUALITY-CONTROL; STRESS; ACIDIFICATION; HOMEOSTASIS; APOPTOSIS; AUTOPHAGY;

D O I：

10.1039/c9cc03114f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we present a dual-site ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the detection of pH in the ER. The probe showed a highly sensitive response to pH in the range of 5.0-7.2, and could be applied for the quantitative measurement of the pH values in the ER during ER stress and dexamethanose-induced stimulation.

引用

页码：10776 / 10779

页数：4