An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

被引：43
|
作者：
Dong, Baoli [1 ]
Song, Wenhui [1 ]
Lu, Yaru [1 ]
Kong, Xiuqi [1 ]
Mehmood, Abdul Hadi [1 ]
Lin, Weiying [1 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Inst Fluorescent Probes Biol Imaging, Sch Mat Sci & Engn, Jinan 250022, Shandong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 72期
关键词：
INTRACELLULAR PH; QUALITY-CONTROL; STRESS; ACIDIFICATION; HOMEOSTASIS; APOPTOSIS; AUTOPHAGY;
D O I：
10.1039/c9cc03114f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we present a dual-site ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the detection of pH in the ER. The probe showed a highly sensitive response to pH in the range of 5.0-7.2, and could be applied for the quantitative measurement of the pH values in the ER during ER stress and dexamethanose-induced stimulation.
引用
收藏
页码：10776 / 10779
页数：4
相关论文
共 45 条
  • [21] A Dansyl-Rhodamine Ratiometric Fluorescent Probe for Hg2+ Based on FRET Mechanism
    Puhui Xie
    Fengqi Guo
    Lingyu Wang
    Sen Yang
    Denghui Yao
    Guoyu Yang
    Journal of Fluorescence, 2015, 25 : 319 - 325
  • [22] A Dansyl-Rhodamine Ratiometric Fluorescent Probe for Hg2+ Based on FRET Mechanism
    Xie, Puhui
    Guo, Fengqi
    Wang, Lingyu
    Yang, Sen
    Yao, Denghui
    Yang, Guoyu
    JOURNAL OF FLUORESCENCE, 2015, 25 (02) : 319 - 325
  • [23] A novel nanogel-based fluorescent probe for ratiometric detection of intracellular pH values
    Cao, Lixia
    Li, Xiaoyan
    Wang, Shuangqing
    Li, Shayu
    Li, Yi
    Yang, Guoqiang
    CHEMICAL COMMUNICATIONS, 2014, 50 (63) : 8787 - 8790
  • [24] Designing a turn-on ultrasensitive fluorescent probe based on ICT-FRET for detection and bioimaging of Hypochlorous acid
    Zhu, Jihua
    Miao, Congcong
    Wang, Xicun
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2023, 294
  • [25] A pH sensitive and,selective ratiometric PAMAM wavelength-shifting bichromophoric system based on PET, FRET and ICT
    Georgiev, Nikolai I.
    Asiri, Abdullah M.
    Qusti, Abdullah H.
    Alamry, Khalid A.
    Bojinov, Vladimir B.
    DYES AND PIGMENTS, 2014, 102 : 35 - 45
  • [26] A ratiometric lysosomal pH probe based on the imidazo[1,5-a]pyridine-rhodamine FRET and ICT system
    Song, Guang-Jie
    Bai, Su-Yun
    Dai, Xi
    Cao, Xiao-Qun
    Zhao, Bao-Xiang
    RSC ADVANCES, 2016, 6 (47): : 41317 - 41322
  • [27] A novel AIRE-based fluorescent ratiometric probe with endoplasmic reticulum-targeting ability for detection of hypochlorite and bioimaging
    Yan, Jin-Long
    Zhang, Ling
    Wu, Wei-Na
    Wang, Yuan
    Xu, Zhi-Hong
    BIOORGANIC CHEMISTRY, 2023, 131
  • [28] A Highly Selective and Sensitive Ratiometric Fluorescent Probe for pH Measurement Based on Fluorescence Resonance Energy Transfer
    Liang Fanghui
    Wang Di
    Ma Pinyi
    Wang Xinghua
    Song Daqian
    Yu Yong
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 31 (05) : 724 - 729
  • [29] A highly selective and sensitive ratiometric fluorescent probe for pH measurement based on fluorescence resonance energy transfer
    Fanghui Liang
    Di Wang
    Pinyi Ma
    Xinghua Wang
    Daqian Song
    Yong Yu
    Chemical Research in Chinese Universities, 2015, 31 : 724 - 729
  • [30] Dual Mechanism of an Intramolecular Charge Transfer (ICT)-FRET-Based Fluorescent Probe for the Selective Detection of Hydrogen Peroxide
    Liang, Xiao
    Xu, Xiaoyi
    Qiao, Dan
    Yin, Zheng
    Shang, Luqing
    CHEMISTRY-AN ASIAN JOURNAL, 2017, 12 (24) : 3187 - 3194
12345