An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

被引：43
|
作者：
Dong, Baoli [1 ]
Song, Wenhui [1 ]
Lu, Yaru [1 ]
Kong, Xiuqi [1 ]
Mehmood, Abdul Hadi [1 ]
Lin, Weiying [1 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Inst Fluorescent Probes Biol Imaging, Sch Mat Sci & Engn, Jinan 250022, Shandong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 72期
关键词：
INTRACELLULAR PH; QUALITY-CONTROL; STRESS; ACIDIFICATION; HOMEOSTASIS; APOPTOSIS; AUTOPHAGY;
D O I：
10.1039/c9cc03114f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we present a dual-site ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the detection of pH in the ER. The probe showed a highly sensitive response to pH in the range of 5.0-7.2, and could be applied for the quantitative measurement of the pH values in the ER during ER stress and dexamethanose-induced stimulation.
引用
收藏
页码：10776 / 10779
页数：4
相关论文
共 45 条
  • [1] A ratiometric fluorescent probe based on FRET mechanism for pH and its cell imaging
    Yue, Zhen-Ming
    Zhai, Shu-Mei
    Wei, Bing-Yu
    Zhao, Bao-Xiang
    Lin, Zhao-Min
    DYES AND PIGMENTS, 2025, 233
  • [2] An FRET-ICT-based ratiometric fluorescent and colorimetric probe for pH monitoring in lysosomes and water
    Li, Zhang-Yi
    Cui, Xiao-Ling
    Xiao, Meng-Min
    Miao, Jun-Ying
    Zhao, Bao-Xiang
    Lin, Zhao-Min
    DYES AND PIGMENTS, 2021, 193 (193)
  • [3] A new insight into the luminescence mechanism of a FRET-ICT-based ratiometric and colorimetric pH probe
    Xu, Honghong
    Chen, Lu
    Yu, Yan
    Huang, Anran
    Hao, Wenxuan
    Xia, Zhicheng
    He, Haixiang
    CHEMICAL PHYSICS LETTERS, 2024, 851
  • [4] A coumarin-naphthalimide-based ratiometric fluorescent probe for nitroxyl (HNO) based on an ICT-FRET mechanism
    Ma, Qiujuan
    Liu, Shuangyu
    Xu, Junhong
    Mao, Guojiang
    Wang, Gege
    Hou, Shuqi
    Ma, Yijie
    Lian, Yujie
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2024, 323
  • [5] Using Nanoliposomes To Construct a FRET-Based Ratiometric Fluorescent Probe for Sensing Intracellular pH Values
    Zhang, Yangyang
    Li, Shilei
    Zhao, Zhenwen
    ANALYTICAL CHEMISTRY, 2016, 88 (24) : 12380 - 12385
  • [6] A novel ratiometric pH probe for extreme acidity based on FRET and PET
    Shen, Shi-Li
    Zhang, Xiao-Fan
    Bai, Su-Yun
    Miao, Jun-Ying
    Zhao, Bao-Xiang
    RSC ADVANCES, 2015, 5 (18): : 13341 - 13346
  • [7] A novel endoplasmic reticulum-targeted ratiometric fluorescent probe based on FRET for the detection of SO2 derivatives
    Li, Zhang-Yi
    Cui, Xiao-Ling
    Yan, Ye-Hao
    Che, Qiao-Ling
    Miao, Jun-Ying
    Zhao, Bao-Xiang
    Lin, Zhao-Min
    DYES AND PIGMENTS, 2021, 188
  • [8] A phenothiazine-rhodamine ratiometric fluorescent probe for Hg2+ based on FRET and ICT
    Zhao, Wenqi
    Liu, Xingliang
    Lv, Haitang
    Fu, Hua
    Yang, Yan
    Huang, Ziping
    Han, Aixia
    TETRAHEDRON LETTERS, 2015, 56 (29) : 4293 - 4298
  • [9] Hypochlorite activatable ratiometric fluorescent probe based on endoplasmic reticulum stress for imaging of atherosclerosis
    Gui, Lijuan
    Yan, Jun
    Zhao, Junyuan
    Wang, Shiya
    Ji, Yingying
    Liu, Ji
    Wu, Jinsheng
    Yuan, Kang
    Liu, Heng
    Deng, Dawei
    Yuan, Zhenwei
    BIOSENSORS & BIOELECTRONICS, 2023, 240
  • [10] A Novel Ratiometric Fluorescent Mercury Probe Based on Deprotonation-ICT Mechanism
    Puhui Xie
    Fengqi Guo
    Sen Yang
    Denghui Yao
    Guoyu Yang
    Lixia Xie
    Journal of Fluorescence, 2014, 24 : 473 - 480
12345