Biological evaluation of substituted quinolines

被引：109
作者：
Franck, X
Fournet, A
Prina, E
Mahieux, R
Hocquemiller, R
Figadère, B
机构：
[1] Univ Paris Sud, Fac Pharm, Lab Pharmacognosie, CNRS,BioCIS, F-92296 Chatenay Malabry, France
[2] IRD, F-75480 Paris, France
[3] Inst Pasteur, Unite Immunophysiol & Parasitisme Intracellulaire, F-75724 Paris, France
[4] Inst Pasteur, Unite Epidemiol & Physiopathol Virus Oncogenes, F-75724 Paris, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期
关键词：
protozoa; HTLV-1; leishmaniases; trypanozomiases;
D O I：
10.1016/j.bmcl.2004.05.026
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 muM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：3635 / 3638
页数：4
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