Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

被引：45

作者：

Adams, Jason W. ^{[1
,2
,3
]}

Cugola, Fernanda R. ^{[1
,2
]}

Muotri, Alysson R. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, Rady Childrens Hosp San Diego, Sch Med, San Diego, CA 92103 USA

[2] Kavli Inst Brain & Mind, Dept Cellular & Mol Med, Stem Cell Program, CARTA, La Jolla, CA 92161 USA

[3] Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USA

来源：

PHYSIOLOGY | 2019年 / 34卷 / 05期

基金：

美国国家卫生研究院;

关键词：

stem cells; organoids; neurodevelopmental disease; disease modeling; PLURIPOTENT STEM-CELLS; MICROGLIA-LIKE CELLS; RETT-SYNDROME; CORTICAL DEVELOPMENT; SPECTRUM DISORDERS; NEURAL DEVELOPMENT; CEREBRAL-CORTEX; IN-VITRO; AUTISM; NEURONS;

D O I：

10.1152/physiol.00005.2019

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

引用

页码：365 / 375

页数：11

共 141 条

[1] Advances in autism genetics: on the threshold of a new neurobiology [J].

Abrahams, Brett S. ;

Geschwind, Daniel H. .

NATURE REVIEWS GENETICS, 2008, 9 (05) :341-355

[2] Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres [J].

Abreu, Celina Monteiro ;

Gama, Lucio ;

Krasemann, Susanne ;

Chesnut, Megan ;

Odwin-Dacosta, Shelly ;

Hogberg, Helena T. ;

Hartung, Thomas ;

Pamies, David .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[3] iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases [J].

Abud, Edsel M. ;

Ramirez, Ricardo N. ;

Martinez, Eric S. ;

Healy, Luke M. ;

Nguyen, Cecilia H. H. ;

Newman, Sean A. ;

Yeromin, Andriy V. ;

Scarfone, Vanessa M. ;

Marsh, Samuel E. ;

Fimbres, Cristhian ;

Caraway, Chad A. ;

Fote, Gianna M. ;

Madany, Abdullah M. ;

Agrawal, Anshu ;

Kayed, Rakez ;

Gylys, Karen H. ;

Cahalan, Michael D. ;

Cummings, Brian J. ;

Antel, Jack P. ;

Mortazavi, Ali ;

Carson, Monica J. ;

Poon, Wayne W. ;

Blurton-Jones, Mathew .

NEURON, 2017, 94 (02) :278-+

[4] Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation [J].

Allende, Maria L. ;

Cook, Emily K. ;

Larman, Bridget C. ;

Nugent, Adrienne ;

Brady, Jacqueline M. ;

Golebiowski, Diane ;

Sena-Esteves, Miguel ;

Tifft, Cynthia J. ;

Proia, Richard L. .

JOURNAL OF LIPID RESEARCH, 2018, 59 (03) :550-563

[5]

[Anonymous], 1953, Am J Public Health Nations Health, V43, P621

[6] FOXG1 is responsible for the congenital variant of Rett syndrome [J].

Ariani, Francesca ;

Hayek, Giuseppe ;

Rondinella, Dalila ;

Artuso, Rosangela ;

Mencarelli, Maria Antonietta ;

Spanhol-Rosseto, Ariele ;

Pollazzon, Marzia ;

Buoni, Sabrina ;

Spiga, Ottavia ;

Ricciardi, Sara ;

Meloni, Ilaria ;

Longo, Ilaria ;

Mari, Francesca ;

Broccoli, Vania ;

Zappella, Michele ;

Renieri, Alessandra .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 83 (01) :89-93

[7] Fused cerebral organoids model interactions between brain regions [J].

Bagley, Joshua A. ;

Reumann, Daniel ;

Bian, Shan ;

Levi-Strauss, Julie ;

Knoblich, Juergen A. .

NATURE METHODS, 2017, 14 (07) :743-+

[8] Fetal Infections and Brain Development [J].

Bale, James F., Jr. .

CLINICS IN PERINATOLOGY, 2009, 36 (03) :639-+

[9] Autism and abnormal development of brain connectivity [J].

Belmonte, MK ;

Allen, G ;

Beckel-Mitchener, A ;

Boulanger, LM ;

Carper, RA ;

Webb, SJ .

JOURNAL OF NEUROSCIENCE, 2004, 24 (42) :9228-9231

[10] Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics [J].

Bergmann, Sonja ;

Lawler, Sean E. ;

Qu, Yuan ;

Fadzen, Colin M. ;

Wolfe, Justin M. ;

Regan, Michael S. ;

Pentelute, Bradley L. ;

Agar, Nathalie Y. R. ;

Cho, Choi-Fong .

NATURE PROTOCOLS, 2018, 13 (12) :2827-2843

← 1 2 3 4 5 6 7 8 9 10 →