The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma

被引：19
作者：
Jiang, Han-yu [1 ]
Zheng, Hui-min [1 ]
Xia, Cheng [1 ]
Li, Xiang [1 ]
Wang, Gang [1 ]
Zhao, Tong [1 ]
Cui, Xiao-nan [2 ]
Wang, Ruo-yu [1 ,3 ]
Liu, Ying [1 ,3 ]
机构：
[1] Dalian Univ, Affiliated Zhongshan Hosp, Dept Oncol, 6 Liberat St, Dalian 116001, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian 116011, Liaoning, Peoples R China
[3] Key Lab Biomarker High Throughput Screening & Tar, Dalian, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2022年 / 15卷
关键词：
bufalin; cancer; therapy; signaling pathways; immunotherapy effect; CANCER-CELLS; AUTOPHAGY; APOPTOSIS; PATHWAY; PROLIFERATION; HIF-1-ALPHA; SORAFENIB; MIGRATION; INVASION; KINASE;
D O I：
10.2147/OTT.S333233
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world with a five-year survival rate of less than 20%. Nonetheless, selecting an appropriate therapeutic agent to inhibit the development of hepatoma cells is still a challenge. Bufalin, a component of the traditional Chinese medicine Chansu, has been shown to inhibit the proliferation, invasion and metastasis of HCC through various signaling pathways. In addition, bufalin and sorafenib demonstrate a synergistic effect in cancer therapeutics. This review highlighted on several focal signaling pathways involved in the inhibitory effects of bufalin on HCC and its synergistic mechanisms with sorafenib. The immunotherapy effect of bufalin has also been discussed as a novel property.
引用
收藏
页码：291 / 298
页数：8
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