Potential α-glucosidase inhibitor from Hylotelephium erythrostictum

In light of the adequate sources for Hylotelephium erythrostictum, its active components have aroused research interest. 2-(3 ',4 '-dihydroxyphenyl)-2,3-dihydro-4,6-dihydroxy-2-(methoxy)3-benzofuranone(1), apigenin(2), diosmetin(3), kaempferol(4), kaempferide(5), rhamnocitrin(6), quercetin(7), and gallic acid(8) were isolated from H. erythrostictum. Rarely occurring naturally, 1 is 2-methoxybenzofuranone type compound against alpha-glucosidase and exhibits a potential inhibitory effect on alpha-glucosidase(IC50 = 1.8 mu M), with a Ki value of 709 nM. In silico molecular docking was performed for the investigation of the inhibition mechanism. H. erythrostictum is a potential source of antidiabetic agent. This information is useful in finding more potent antidiabetic candidates from medicinal plants for the clinical development of therapeutics.