Potential α-glucosidase inhibitor from Hylotelephium erythrostictum

被引：22

作者：

Quan, Yin-Sheng ^{[1
]}

Zhang, Xiao-Yong ^{[2
]}

Yin, Xiu-Mei ^{[1
]}

Wang, Si-Hong ^{[2
]}

Jin, Li-Li ^{[1
]}

机构：

[1] Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China

[2] Yanbian Univ, Anal & Inspect Ctr, Yanji 133002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Hylotelephium erythrostictum; 2-(Methoxy)-3-benzofuranone; alpha-Glucosidase inhibitor; In silico molecular docking; Antidiabetic candidate; CHEMICAL-CONSTITUENTS; IN-SILICO; MECHANISM;

D O I：

10.1016/j.bmcl.2020.127665

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In light of the adequate sources for Hylotelephium erythrostictum, its active components have aroused research interest. 2-(3 ',4 '-dihydroxyphenyl)-2,3-dihydro-4,6-dihydroxy-2-(methoxy)3-benzofuranone(1), apigenin(2), diosmetin(3), kaempferol(4), kaempferide(5), rhamnocitrin(6), quercetin(7), and gallic acid(8) were isolated from H. erythrostictum. Rarely occurring naturally, 1 is 2-methoxybenzofuranone type compound against alpha-glucosidase and exhibits a potential inhibitory effect on alpha-glucosidase(IC50 = 1.8 mu M), with a Ki value of 709 nM. In silico molecular docking was performed for the investigation of the inhibition mechanism. H. erythrostictum is a potential source of antidiabetic agent. This information is useful in finding more potent antidiabetic candidates from medicinal plants for the clinical development of therapeutics.

引用

页数：4

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