Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children

被引：2
|
作者：
Sanogo, Bintou [1 ]
Ouermi, Alain Saga [2 ]
Barro, Makoura [1 ]
Millogo, Anselme [3 ]
Ouattara, Ad Bafa Ibrahim [4 ]
Abdoul Salam, Ouedraogo [3 ]
Nacro, Boubacar [1 ]
机构：
[1] Univ Hosp Ctr Souro Sanou CHUSS, Dept Pediat, Bobo Dioulasso, Burkina Faso
[2] Reg Teaching Hosp Ouahigouya, Dept Pediat, Ouahigouya, Burkina Faso
[3] Univ Hosp Ctr Souro Sanou CHUSS Bobo Dioulasso, Lab Bacteriol Virol, Bobo Dioulasso, Burkina Faso
[4] Reg Hosp Gaoua, Dept Pediat, Gaoua, Burkina Faso
来源：
PLOS ONE | 2020年 / 15卷 / 11期
关键词：
RELEASE ASSAYS; SKIN-TEST; MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; IMPROVES; YOUNGER;
D O I：
10.1371/journal.pone.0241789
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objective Evaluate the performance of QuantiFERON (R) -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. Method Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. Results Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. Conclusion QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.
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页数：12
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