Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children

被引：2

作者：

Sanogo, Bintou ^{[1
]}

Ouermi, Alain Saga ^{[2
]}

Barro, Makoura ^{[1
]}

Millogo, Anselme ^{[3
]}

Ouattara, Ad Bafa Ibrahim ^{[4
]}

Abdoul Salam, Ouedraogo ^{[3
]}

Nacro, Boubacar ^{[1
]}

机构：

[1] Univ Hosp Ctr Souro Sanou CHUSS, Dept Pediat, Bobo Dioulasso, Burkina Faso

[2] Reg Teaching Hosp Ouahigouya, Dept Pediat, Ouahigouya, Burkina Faso

[3] Univ Hosp Ctr Souro Sanou CHUSS Bobo Dioulasso, Lab Bacteriol Virol, Bobo Dioulasso, Burkina Faso

[4] Reg Hosp Gaoua, Dept Pediat, Gaoua, Burkina Faso

来源：

PLOS ONE | 2020年 / 15卷 / 11期

关键词：

RELEASE ASSAYS; SKIN-TEST; MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; IMPROVES; YOUNGER;

D O I：

10.1371/journal.pone.0241789

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective Evaluate the performance of QuantiFERON (R) -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. Method Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. Results Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. Conclusion QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.

引用

页数：12

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