Synthesis at the molecular frontier

被引：477

作者：

Wender, Paul A. ^{[1
,2
]}

Miller, Benjamin L. ^{[3
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA

[3] Univ Rochester, Sch Med & Dent, Rochester, NY 14642 USA

来源：

NATURE | 2009年 / 460卷 / 7252期

基金：

美国国家科学基金会;

关键词：

ORGANIC-SYNTHESIS; ORIENTED SYNTHESIS; NATURAL-PRODUCTS; IN-VITRO; DISCOVERY; CHEMISTRY; ANALOGS; IDENTIFICATION; PROSTRATIN; CONVERSION;

D O I：

10.1038/460197a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Driven by remarkable advances in the understanding of structure and reaction mechanisms, organic synthesis will be increasingly directed to producing bioinspired and newly designed molecules. © 2009 Macmillan Publishers Limited. All rights reserved.

引用

页码：197 / 201

页数：5

共 50 条

[1]

[Anonymous], 2007, WAY SYNTHESIS EVOLUT

[2]

Chanon M, 1998, SYNTHESIS-STUTTGART, P1559

[3] From α-cedrene to crinipellin B and onward:: 25 years of the alkene-arene meta-photocycloaddition reaction in natural product synthesis [J].

Chappell, David ;

Russell, Andrew T. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (24) :4409-4430

[4] Thermal, catalytic, regiospecific functionalization of alkanes [J].

Chen, HY ;

Schlecht, S ;

Semple, TC ;

Hartwig, JF .

SCIENCE, 2000, 287 (5460) :1995-1997

[5] A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis [J].

Chen, Mark S. ;

White, M. Christina .

SCIENCE, 2007, 318 (5851) :783-787

[6] Dynamic combinatorial chemistry [J].

Corbett, Peter T. ;

Leclaire, Julien ;

Vial, Laurent ;

West, Kevin R. ;

Wietor, Jean-Luc ;

Sanders, Jeremy K. M. ;

Otto, Sijbren .

CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711

[7]

Corey E.J., 2007, MOL MED

[8] THE TROUBLE WITH SYNTHESIS [J].

CORNFORTH, JW .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1993, 46 (02) :157-170

[9] THE TANDEM RADICAL CYCLIZATION APPROACH TO ANGULAR TRIQUINANES - MODEL STUDIES AND THE TOTAL SYNTHESIS OF (+/-)-SILPHIPERFOLENE AND (+/-)-9-EPISILPHIPERFOLENE [J].

CURRAN, DP ;

KUO, SC .

TETRAHEDRON, 1987, 43 (23) :5653-5661

[10] Biosynthesis of Aromatic Polyketides in Bacteria [J].

Das, Abhirup ;

Khosla, Chaitan .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (05) :631-639

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