NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

被引：174
作者：
Guebre-Xabier, Mimi [1 ]
Patel, Nita [1 ]
Tian, Jing-Hui [1 ]
Zhou, Bin [1 ]
Maciejewski, Sonia [1 ]
Lam, Kristal [1 ]
Portnoff, Alyse D. [1 ]
Massare, Michael J. [1 ]
Frieman, Matthew B. [2 ]
Piedra, Pedro A. [3 ,4 ]
Ellingsworth, Larry [1 ]
Glenn, Gregory [1 ]
Smith, Gale [1 ]
机构：
[1] Novavax Inc, 21 Firstfield Rd, Gaithersburg, MD 20878 USA
[2] Univ Maryland, Sch Med, 685 West Baltimore St, Baltimore, MD 21201 USA
[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[4] Baylor Coll Med, Pediat, Houston, TX 77030 USA
来源：
VACCINE | 2020年 / 38卷 / 50期
关键词：
SARS-CoV-2; COVID-19; Spike glycoprotein; NVX-CoV2373; nanoparticles; Matrix-M adjuvant; Nonhuman primate;
D O I：
10.1016/j.vaccine.2020.10.064
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective efficacy of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length SARS-CoV-2 spike (S) glycoprotein stabilized in the prefusion conformation. Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-MTM adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease. (C) 2020 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：7892 / 7896
页数：5
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