Adjuvant chemotherapy for resected colorectal cancer metastases: literature review and meta-analysis

被引：72

作者：

Brandi, Giovanni ^{[1
,2
]}

De Lorenzo, Stefania ^{[1
]}

Nannini, Margherita ^{[1
]}

Curti, Stefania ^{[3
]}

Ottone, Marta ^{[3
]}

Dall'Olio, Filippo Gustavo ^{[1
]}

Barbera, Maria Aurelia ^{[1
]}

Pantaleo, Maria Abbondanza ^{[1
,2
]}

Biasco, Guido ^{[1
,2
]}

机构：

[1] Univ Bologna, St Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy

[2] Univ Bologna, G Prodi Interdept Ctr Canc Res, I-40138 Bologna, Italy

[3] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 02期

关键词：

Liver metastases; Adjuvant chemotherapy; Metastasectomy; Colorectal cancer; Adjuvant hepatic artery infusion; RANDOMIZED PHASE-III; HEPATIC-ARTERIAL-INFUSION; OXALIPLATIN-BASED CHEMOTHERAPY; CLINICAL-PRACTICE GUIDELINES; LONG-TERM SURVIVAL; LIVER METASTASES; COLON-CANCER; 1ST-LINE TREATMENT; RADIOFREQUENCY ABLATION; SYSTEMIC CHEMOTHERAPY;

D O I：

10.3748/wjg.v22.i2.519

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence (based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.

引用

页码：519 / 533

页数：15

共 118 条

[1] Impact of the type and modalities of preoperative chemotherapy on the outcome of liver resection for colorectal metastases [J].

Adam, R. ;

Barroso, E. ;

Laurent, C. ;

Nuzzo, G. ;

Hubert, C. ;

Mentha, G. ;

Ijzermans, J. ;

Capussotti, L. ;

Lopezben, S. ;

Mirza, D. ;

Kaiser, G. ;

Oussoultzoglou, E. ;

Gruenberger, T. ;

Poston, G. J. ;

Skipenko, O. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)

[2] Repeat hepatectomy for colorectal liver metastases [J].

Adam, R ;

Bismuth, H ;

Castaing, D ;

Waechter, F ;

Navarro, F ;

Abascal, A ;

Majno, P ;

Engerran, L .

ANNALS OF SURGERY, 1997, 225 (01) :51-60

[3] Liver resection for colorectal metastases - The third hepatectomy [J].

Adam, R ;

Pascal, G ;

Azoulay, D ;

Tanaka, K ;

Castaing, D ;

Bismuth, H .

ANNALS OF SURGERY, 2003, 238 (06) :871-883

[4] Two-stage hepatectomy approach for initially unresectable colorectal hepatic metastases [J].

Adam, Rene ;

Miller, Rafael ;

Pitombo, Marcos ;

Wicherts, Dennis A. ;

de Haas, Robbert J. ;

Bitsakou, Georgia ;

Aloia, Thomas .

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2007, 16 (03) :525-+

[5] Effect of Oxaliplatin, Fluorouracil, and Leucovorin With or Without Cetuximab on Survival Among Patients With Resected Stage III Colon Cancer A Randomized Trial [J].

Alberts, Steven R. ;

Sargent, Daniel J. ;

Nair, Suresh ;

Mahoney, Michelle R. ;

Mooney, Margaret ;

Thibodeau, Stephen N. ;

Smyrk, Thomas C. ;

Sinicrope, Frank A. ;

Chan, Emily ;

Gill, Sharlene ;

Kahlenberg, Morton S. ;

Shields, Anthony F. ;

Quesenberry, James T. ;

Webb, Thomas A. ;

Farr, Gist H., Jr. ;

Pockaj, Barbara A. ;

Grothey, Axel ;

Goldberg, Richard M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (13) :1383-1393

[6] Alternating Systemic and Hepatic Artery Infusion Therapy for Resected Liver Metastases From Colorectal Cancer: A North Central Cancer Treatment Group (NCCTG)/National Surgical Adjuvant Breast and Bowel Project (NSABP) Phase II Intergroup Trial, N9945/CI-66 [J].

Alberts, Steven R. ;

Roh, Mark S. ;

Mahoney, Michelle R. ;

O'Connell, Michael J. ;

Nagorney, David M. ;

Wagman, Lawrence ;

Smyrk, Thomas C. ;

Weiland, Timothy L. ;

Lai, Lily Lau ;

Schwarz, Roderich E. ;

Molina, Roy ;

Dentchev, Todor ;

Bolton, John S. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (05) :853-858

[7] Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08 [J].

Allegra, Carmen J. ;

Yothers, Greg ;

O'Connell, Michael J. ;

Sharif, Saima ;

Petrelli, Nicholas J. ;

Colangelo, Linda H. ;

Atkins, James N. ;

Seay, Thomas E. ;

Fehrenbacher, Louis ;

Goldberg, Richard M. ;

O'Reilly, Seamus ;

Chu, Luis ;

Azar, Catherine A. ;

Lopa, Samia ;

Wolmark, Norman .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (01) :11-16

[8] Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].

Andre, T ;

Boni, C ;

Mounedji-Boudiaf, L ;

Navarro, M ;

Tabernero, J ;

Hickish, T ;

Topham, C ;

Zaninelli, M ;

Clingan, P ;

Bridgewater, J ;

Tabah-Fisch, I ;

de Gramont, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351

[9]

Andre T, 2004, Cancer Treat Rev, V30, P711

[10] Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial [J].

Andre, Thierry ;

Boni, Corrado ;

Navarro, Matilde ;

Tabernero, Josep ;

Hickish, Tamas ;

Topham, Clare ;

Bonetti, Andrea ;

Clingan, Philip ;

Bridgewater, John ;

Rivera, Fernando ;

de Gramont, Aimery .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (19) :3109-3116

← 1 2 3 4 5 6 7 8 9 10 →