The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

被引：65
作者：
Ma, Sufang [1 ]
Fang, De-Cai [1 ]
Ning, Baoming [2 ]
Li, Minfeng [1 ]
He, Lan [1 ,2 ]
Gong, Bing [1 ,3 ]
机构：
[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
[2] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China
[3] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 49期
基金：
美国国家科学基金会;
关键词：
MODULATING FLUORESCENCE PROPERTIES; NO; INDICATORS; PRINCIPLE; STRATEGY; MONOXIDE; SENSORS; CELLS;
D O I：
10.1039/c4cc01142b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A rationally designed small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism has been developed. Attaching a NO-responsive dihydropyridine pendant group to a fluorophore led to a probe that displays a very high sensitivity to NO concentrations down to the low nM range and a very high specificity to NO while being insensitive to other oxidative oxygen/nitrogen species that often interfere with the sensing of NO.
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页码：6475 / 6478
页数：4
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