The Role of the Pericardium in Heart Failure Implications for Pathophysiology and Treatment

被引：130
作者：
Borlaug, Barry A. [1 ]
Reddy, Yogesh N., V [1 ]
机构：
[1] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA
来源：
JACC-HEART FAILURE | 2019年 / 7卷 / 07期
基金：
美国国家卫生研究院;
关键词：
heart failure; hemodynamics; pericardium; VENTRICULAR DIASTOLIC PRESSURE; RIGHT ATRIAL PRESSURE; VOLUME; CONSTRAINT; MECHANISM; HYPERTENSION; ANGIOTENSIN; DYSFUNCTION; CAPACITANCE; EXERCISE;
D O I：
10.1016/j.jchf.2019.03.021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies. (C) 2019 by the American College of Cardiology Foundation.
引用
收藏
页码：574 / 585
页数：12
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