Genomic expansion across the albumin gene family on human chromosome 4q is directional

被引：2

作者：

Nishio, H

Hamdi, HK

Dugaiczyk, A ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA

[2] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

来源：

BIOLOGICAL CHEMISTRY | 1999年 / 380卷 / 12期

基金：

美国国家科学基金会;

关键词：

centromere; repetitive DNA; symmetry;

D O I：

10.1515/BC.1999.183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene family. These repetitive motifs provide an internal reference, allowing observations of evolutionary changes within a single line (human) of evolutionary descent. The four genes and three intergenic regions between them increase in size as they get closer to the centromere. An invasion by multiple repetitive DNA elements may account, in part, for this expansion.

引用

页码：1431 / 1434

页数：4

共 31 条

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