Evaluation of Novel Antibiotic-Eluting Thermoresponsive Chitosan-PDEAAm Based Wound Dressings

被引：16

作者：

Ngadaonye, Jude I. ^{[1
]}

Geever, Luke M. ^{[1
]}

McEvoy, Kelsey E. ^{[2
]}

Killion, John ^{[1
]}

Brady, Damien B. ^{[2
]}

Higginbotham, Clement L. ^{[1
]}

机构：

[1] Athlone Inst Technol, Res Hub, Mat Res Inst, Athlone, Westmeath, Ireland

[2] Athlone Inst Technol, Biosci Res Inst, Res Hub, Athlone, Ireland

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 17期

关键词：

Antimicrobials; chitosan; LCST; peel adhesion; poly(N; N-diethylacrylamide); wound healing; WATER-VAPOR TRANSMISSION; CROSS-LINKED CHITOSAN; IN-VITRO; DRUG-DELIVERY; CONTROLLED-RELEASE; THERMOSENSITIVE MEMBRANE; ANTIBACTERIAL ACTIVITY; THERMAL-PROPERTIES; POLYVINYL-ALCOHOL; FILMS;

D O I：

10.1080/00914037.2014.886224

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Thermoresponsive interpenetrating polymer networks were synthesized via rapid photo-polymerization and crosslinking of DEAAm in the presence of chitosan. The dressings are transparent, permeable to moisture vapor but impermeable to bacteria. They possessed negative temperature-dependent swelling properties, hence, swelled and became less adhesive at low temperatures, as demonstrated using peel adhesion tests. Water vapor permeability values of the chitosan-PDEAAm hydrogel films were in the typical and desired range for commercial wound dressings. Antibacterial activity studies demonstrated the ability of the dressings to control the release of incorporated antibiotics, which can enhance wound healing by enabling bacterial inhibition.

引用

页码：873 / 883

页数：11

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