Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

被引：138

作者：

Brewer, J. B. ^{[1
,2
]}

Magda, S. ^{[3
]}

Airriess, C. ^{[3
]}

Smith, M. E. ^{[3
]}

机构：

[1] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[3] CorTechs Labs, La Jolla, CA USA

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2009年 / 30卷 / 03期

关键词：

MILD COGNITIVE IMPAIRMENT; MRI DATA;

D O I：

10.3174/ajnr.A1402

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD.

引用

页码：578 / 580

页数：3

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