From gene action to reactive genomes

被引：66

作者：

Keller, Evelyn Fox ^{[1
]}

机构：

[1] MIT, Program Sci Technol & Soc, Cambridge, MA 02139 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2014年 / 592卷 / 11期

关键词：

RNA;

D O I：

10.1113/jphysiol.2014.270991

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Poised at a critical turning point in the history of genetics, recent work (e.g. in genomics, epigenetics, genomic plasticity) obliges us to critically reexamine many of our most basic concepts. For example, I argue that genomic research supports a radical transformation in our understanding of the genome - a shift from an earlier conception of that entity as an effectively static collection of active genes to that of a dynamic and reactive system dedicated to the context specific regulation of protein-coding sequences.

引用

页码：2423 / 2429

页数：7

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