The effect of hyperthermia on micronucleus induction by mutagens in mice

被引：13

作者：

Asanami, S ^{[1
]}

Shimono, K ^{[1
]}

机构：

[1] Otsuka Pharmaceut Factory, Naruto Res Inst, Tokushima 7728601, Japan

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1999年 / 446卷 / 02期

关键词：

micronuclei; mouse; hyperthermia; colchicine; cyclophosphamide; 5-fluorouracil; mitomycin C;

D O I：

10.1016/S1383-5718(99)00156-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We administered mitomycin C (0.5 mg/kg) intraperitoneally to hyperthermic-treated mice and examined the effect of hyperthermia on micronucleus induction. Hyperthermia enhanced micronucleus induction. The timing of chemical administration relative to the start of hyperthermic treatment (37 degrees C ambient temperature) influenced micronucleus frequency, and the effect was greatest 2 h after the start of hyperthermic treatment. But the hyperthermic treatment did not change the time course of micronucleus induction. In addition, we investigated the effect of hyperthermia on micronucleus induction by chemicals with different modes of action, i.e., alkylating agents (mitomycin C at 0.1-0.5 mg/kg, cyclophosphamide at 1.25-10 mg/kg), a spindle poison (colchicine at 0.05-1.0 mg/kg), and an antimetabolite (5-fluorouracil at: 2.5-50 mg/kg). Hyperthermia enhanced only the clastogenicity of alkylating agents. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：149 / 154

页数：6

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