Preliminary Study on Pain Reduction of Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats by Carbon Dioxide Laser Moxibustion

被引：12

作者：

Wu, Fan ^{[1
]}

Zhang, Ruixing ^{[2
]}

Shen, Xueyong ^{[1
]}

Lao, Lixing ^{[3
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

[2] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA

[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷

关键词：

ADULT ARTICULAR CHONDROCYTES; NEUROPATHIC PAIN; MATRIX METALLOPROTEINASE-13; JOINT PAIN; MODEL; HYPERALGESIA; MECHANISMS; RECEPTOR; INHIBITION; EXPRESSION;

D O I：

10.1155/2014/754304

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In order to study the effects of CO2 laser moxibustion on the pain and inflammatory cytokine expression in the spinal dorsal horn of rats with monosodium iodoacetate- (MIA-) induced knee osteoarthritis (KOA), we designed an experiment by randomly assigning 8 SD rats into 3 groups, namely, a CO2 laser moxibustion group, a sham treatment group, and a blank control group. The treatment group received a laser moxibustion on acupoint Dubi (ST 35; 5 min/treatment, 1 treatment/day) for 8 days, and after treatment, the rats exhibited significantly increased interhindpaw differences compared with their preinduction values. Meanwhile, cytokine microarray analysis showed that one cytokine (TIMP-1) was significantly upregulated and two cytokines (Agrin and MMP-8) were significantly downregulated in treatment group. The present study suggested that CO2 laser moxibustion created certain pain reduction in the rats with MIA-induced KOA and significantly inhibited the expression of most inflammatory cytokines in the ipsilateral spinal dorsal horn.

引用

页数：7

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