High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s

被引：138

作者：

Wieser, Wolfgang ^{[1
]}

Draxinger, Wolfgang ^{[1
]}

Klein, Thomas ^{[1
]}

Karpf, Sebastian ^{[1
]}

Pfeiffer, Tom ^{[1
]}

Huber, Robert ^{[1
,2
]}

机构：

[1] Univ Munich, Fak Phys, Lehrstuhl BioMol Opt, D-80538 Munich, Germany

[2] Univ Lubeck, Inst Biomed Opt, Lubeck, Germany

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 09期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; GRAPHICS PROCESSING UNIT; DOMAIN MODE-LOCKING; SWEPT SOURCE OCT; ULTRAHIGH-SPEED; ANTERIOR SEGMENT; HUMAN RETINA; AXIAL SCANS; MEGAHERTZ OCT; LASER;

D O I：

10.1364/BOE.5.002963

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a 1300 nm OCT system for volumetric real-time live OCT acquisition and visualization at 1 billion volume elements per second. All technological challenges and problems associated with such high scanning speed are discussed in detail as well as the solutions. In one configuration, the system acquires, processes and visualizes 26 volumes per second where each volume consists of 320 x 320 depth scans and each depth scan has 400 usable pixels. This is the fastest real-time OCT to date in terms of voxel rate. A 51 Hz volume rate is realized with half the frame number. In both configurations the speed can be sustained indefinitely. The OCT system uses a 1310 nm Fourier domain mode locked (FDML) laser operated at 3.2 MHz sweep rate. Data acquisition is performed with two dedicated digitizer cards, each running at 2.5 GS/s, hosted in a single desktop computer. Live real-time data processing and visualization are realized with custom developed software on an NVidia GTX 690 dual graphics processing unit (GPU) card. To evaluate potential future applications of such a system, we present volumetric videos captured at 26 and 51 Hz of planktonic crustaceans and skin. (C)2014 Optical Society of America

引用

页码：2963 / 2977

页数：15

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