Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

被引：562

作者：

Sornson, MW

Wu, W

Dasen, JS

Flynn, SE

Norman, DJ

OConnell, SM

Gukovsky, I

Carriere, C

Ryan, AK

Miller, AP

Zuo, L

Gleiberman, AS

Andersen, B

Beamer, WG

Rosenfeld, MG

机构：

[1] UNIV CALIF SAN DIEGO,DEPT & SCH MED,HOWARD HUGHES MED INST,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,DEPT & SCH MED,BIOL GRAD PROGRAM,LA JOLLA,CA 92093

[3] UNIV CALIF SAN DIEGO,DEPT & SCH MED,BIOMED SCI GRAD PROGRAM,LA JOLLA,CA 92093

[4] SEQUANA THERAPEUT INC,LA JOLLA,CA 92037

[5] JACKSON LAB,BAR HARBOR,ME 04609

来源：

NATURE | 1996年 / 384卷 / 6607期

关键词：

D O I：

10.1038/384327a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.

引用

页码：327 / 333

页数：7

共 48 条

[1] The ames dwarf gene is required for Pit-1 gene activation [J].