Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03

被引：25

作者：

Neill, D

Curran, MD

Middleton, D

Mawhinney, H

Edwardson, JA

Mckeith, I

Ballard, C

Morris, C

Ince, P

Jaros, E

Perry, R

机构：

[1] Newcastle Gen Hosp, Inst Hlth Elderly, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] S Tyneside Dist Hosp, S Shields NE34 OPL, Tyne & Wear, England

[3] Belfast City Hosp, No Ireland Reg Tissue Typing Labs, Belfast BT9 7TS, Antrim, North Ireland

[4] Queens Univ Belfast, Belfast, Antrim, North Ireland

[5] Univ Ulster, Belfast, Antrim, North Ireland

来源：

NEUROSCIENCE LETTERS | 1999年 / 275卷 / 02期

关键词：

Alzheimer's disease; dementia; Major Histocompatibility Complex; HLA-DR; apolipoprotein E; chromosome; 6;

D O I：

10.1016/S0304-3940(99)00761-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The allele frequency of the HLA-DRB1gene was compared between groups of 48 clinically diagnosed elderly Alzheimer's disease (AD) cases and 44 pathologically confirmed elderly control cases. Specific primers were used to PCR amplify the highly polymorphic second exon of HLA-DRB1 using DNA extracted from blood samples or frozen brain tissue. The allele type was identified using sequence specific oligonucleotide probes. The results showed an increased frequency of DRB1*03 (P < 0.006) and decreased frequency of DRB1*09 (P < 0.049) in the AD cases compared with the controls. The results suggest that DRB1*03 is associated with an increased risk and DRB1*09 a possible decreased risk for the development of late-onset AD with first detectable clinical symptoms occurring at age 75 years or greater. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：137 / 140

页数：4

共 22 条

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