Possible novel targets for therapeutic angiogenesis

被引：29

作者：

Cristofaro, Brunella ^{[1
]}

Emanueli, Costanza ^{[1
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Div Expt Cardiovasc Med, Bristol, Avon, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 02期

关键词：

ENDOTHELIAL PROGENITOR CELLS; BONE MORPHOGENETIC PROTEINS; GROWTH-FACTOR; SONIC-HEDGEHOG; NEUROTROPHIC FACTOR; CARDIOVASCULAR DEVELOPMENT; VASCULAR MORPHOGENESIS; NETRIN RECEPTOR; NOTCH PATHWAY; EPH RECEPTORS;

D O I：

10.1016/j.coph.2008.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An increasing number of studies about the molecular basis of angiogenesis are rapidly disclosing novel signal pathways involved in the blood vessel formation process. This review will focus on bone morphogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins. These recently discovered angiogenesis mediators are involved in vascular development during embryogenesis and, interestingly, they are shared between the nervous and vascular systems. They represent new potential targets in the vasculature and suggest novel therapeutic opportunities.

引用

页码：102 / 108

页数：7

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