Can efficiency of the photosensitizer be predicted by its photostability in solution?

被引：29

作者：

Ferreira, J. ^{[1
,2
]}

Menezes, P. F. C. ^{[1
]}

Sibata, C. H. ^{[3
]}

Allison, R. R. ^{[3
]}

Zucoloto, S. ^{[2
]}

Castro e Silva, O., Jr. ^{[2
]}

Bagnato, V. S. ^{[1
]}

机构：

[1] Univ Sao Paulo, IFSC, BR-13560970 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, FMRP, Sao Paulo, Brazil

[3] E Carolina Univ, Brody Sch Med, Greenville, NC USA

来源：

LASER PHYSICS | 2009年 / 19卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

MEDIATED PHOTODYNAMIC THERAPY; HEMATOPORPHYRIN; PHOTOPRODUCTS; PHOTOGEM(R); CANCER; CELLS; PHOTOTRANSFORMATION; CYTOTOXICITY; PHOTOFRIN(R); DERIVATIVES;

D O I：

10.1134/S1054660X09170071

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We have investigated a possible correlation between the photostability and photodynamic efficacy for different photosensitizers; hematoporphyrin derivatives and chlorines. To perform such analysis, we combined the depth of necrosis (d (nec)) measurement, expressed by the light threshold dose and a photodegradation parameter, measured from investigation of photosensitizer degradation in solution. The d (nec) analysis allows us to determine the light threshold dose and compare its value with the existent results in the literature. The use of simple models to understand basic features of Photodynamic Therapy (PDT) may contribute to the solid establishment of dosimetry in PDT, enhancing its use in the clinical management of cancers and others lesions. Using hematoporphyrin derivatives and chlorines photosensitizers we investigated their properties related to the photodegradation in solution and the light threshold dose (D (th)) in rat livers.

引用

页码：1932 / 1938

页数：7

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