Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

被引：0

作者：

Combariza, Miguel E. ^{[1
]}

Yu, Xinghuo ^{[1
]}

Nesbitt, Warwick ^{[1
,2
]}

Tovar-Lopez, Francisco ^{[1
]}

Rabus, Dominik G. ^{[1
,3
]}

Mitchell, Arnan ^{[1
]}

机构：

[1] RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic, Australia

[2] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic 3004, Australia

[3] Burkert Fluid Control Syst, Ingelfingen, Germany

来源：

MICRO+NANO MATERIALS, DEVICES, AND SYSTEMS | 2015年 / 9668卷

关键词：

Dynamic modelling; automation; flow control; microfluidics; blood clotting; high-throughput; diagnostics; PLATELET THROMBUS FORMATION; FLOW-CHAMBER SYSTEM; ON-A-CHIP; IDENTIFICATION; AGGREGATION; DEVICES; MICROCHANNELS; EXERCISE;

D O I：

10.1117/12.2202367

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.

引用

页数：10

共 32 条

[1] A novel multishear microdevice for studying cell mechanics [J].

Chau, Lien ;

Doran, Michael ;

Cooper-White, Justin .

LAB ON A CHIP, 2009, 9 (13) :1897-1902

[2] Nonlinear Modeling and Control of Human Heart Rate Response During Exercise With Various Work Load Intensities [J].

Cheng, Teddy M. ;

Savkin, Andrey V. ;

Celler, Branko G. ;

Su, Steven W. ;

Wang, Lu .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2008, 55 (11) :2499-2508

[3] Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives [J].

Chiu, Jeng-Jiann ;

Chien, Shu .

PHYSIOLOGICAL REVIEWS, 2011, 91 (01) :327-387

[4] Microfluidics and Coagulation Biology [J].

Colace, Thomas V. ;

Tormoen, Garth W. ;

McCarty, Owen J. T. ;

Diamond, Scott L. .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 15, 2013, 15 :283-303

[5] Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow Role of Thrombin With and Without Fibrin [J].

Colace, Thomas V. ;

Muthard, Ryan W. ;

Diamond, Scott L. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (06) :1466-+

[6] Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices [J].

Combariza, Miguel E. ;

Yu, Xinghuo ;

Nesbitt, Warwick S. ;

Mitchell, Arnan ;

Tovar-Lopez, Francisco J. .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2015, 62 (07) :1718-1727

[7] Well Plate Microfluidic System for Investigation of Dynamic Platelet Behavior Under Variable Shear Loads [J].

Conant, Carolyn G. ;

Schwartz, Michael A. ;

Beecher, Jody E. ;

Rudoff, Roger C. ;

Ionescu-Zanetti, Cristian ;

Nevill, J. Tanner .

BIOTECHNOLOGY AND BIOENGINEERING, 2011, 108 (12) :2978-2987

[8] Using Well-Plate Microfluidic Devices to Conduct Shear-Based Thrombosis Assays [J].

Conant, Carolyn G. ;

Nevill, J. Tanner ;

Zhou, Zhou ;

Dong, Jing-Fei ;

Schwartz, Michael A. ;

Ionescu-Zanetti, Cristian .

JALA, 2011, 16 (02) :148-152

[9] Lab-on-a-chip: microfluidics in drug discovery [J].

Dittrich, PS ;

Manz, A .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :210-218

[10] Shear-dependent tether formation during platelet translocation on von Willebrand factor [J].

Dopheide, SM ;

Maxwell, MJ ;

Jackson, SP .

BLOOD, 2002, 99 (01) :159-167

← 1 2 3 4 →