Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with preeclampsia

被引：6

作者：

Laasanen, J

Heinonen, S ^{[1
]}

Hiltunen, M

Mannermaa, A

Laakso, M

机构：

[1] Kuopio Univ Hosp, Dept Obstet & Gynecol, Kuopio 70211, Finland

[2] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland

[3] Kuopio Univ Hosp, Div Diagnost Serv, Chromosome & DNA Lab, Kuopio 70211, Finland

[4] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland

来源：

EARLY HUMAN DEVELOPMENT | 2002年 / 69卷 / 1-2期

关键词：

preeclampsia; polymorphism; PPAR gamma;

D O I：

10.1016/S0378-3782(02)00069-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia. Methods: The study involved 133 preeclamptic and 115 healthy control women who were genotyped for a known functional variant of the PPARgamma gene using single-strand conformation polymorphism (SSCP) analysis. Results: We found no association between PPARgamma polymorphism and the occurrence of preeclampsia. In affected women, the clinical course of preeclampsia was no different among the three PPARgamma genotypes. Conclusion: Our data does not support a role for PPARgamma gene polymorphism in the pathogenesis of preeclampsia. Accordingly, it is unlikely that PPARgamma polymorphism influences the severity of preeclampsia. Precis: There is no association between PPARgamma polymorphism and the occurrence or severity of preeclampsia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：77 / 82

页数：6