Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with preeclampsia

被引：6
作者：
Laasanen, J
Heinonen, S [1 ]
Hiltunen, M
Mannermaa, A
Laakso, M
机构：
[1] Kuopio Univ Hosp, Dept Obstet & Gynecol, Kuopio 70211, Finland
[2] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland
[3] Kuopio Univ Hosp, Div Diagnost Serv, Chromosome & DNA Lab, Kuopio 70211, Finland
[4] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland
来源：
EARLY HUMAN DEVELOPMENT | 2002年 / 69卷 / 1-2期
关键词：
preeclampsia; polymorphism; PPAR gamma;
D O I：
10.1016/S0378-3782(02)00069-5
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia. Methods: The study involved 133 preeclamptic and 115 healthy control women who were genotyped for a known functional variant of the PPARgamma gene using single-strand conformation polymorphism (SSCP) analysis. Results: We found no association between PPARgamma polymorphism and the occurrence of preeclampsia. In affected women, the clinical course of preeclampsia was no different among the three PPARgamma genotypes. Conclusion: Our data does not support a role for PPARgamma gene polymorphism in the pathogenesis of preeclampsia. Accordingly, it is unlikely that PPARgamma polymorphism influences the severity of preeclampsia. Precis: There is no association between PPARgamma polymorphism and the occurrence or severity of preeclampsia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：77 / 82
页数：6
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