Signals from the X: signal transduction and X-linked mental retardation

被引：11

作者：

Barnes, AP ^{[1
]}

Milgram, SL ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Neurodev Disorders Res Ctr, Chapel Hill, NC 27599 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2002年 / 20卷 / 3-5期

关键词：

mental retardation (MR); cyclic AMP response element binding protein (CREB); CREB-binding protein (CBP);

D O I：

10.1016/S0736-5748(02)00016-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The dramatic increase in genomic information is allowing the rapid identification of genes that are altered in mental retardation (MR). It is necessary to place their resulting gene products in their cellular context to understand how they may have contributed to a patient's cognitive deficits. This review will consider signaling molecules that have been implicated in X-linked MR and the known pathways by which these proteins covey information will be delineated. The proteins discussed include four distinct classes: transmembrane receptors, guanine nucleotide related proteins, kinases, and translational regulators. (C) 2002 ISDN. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：397 / 406

页数：10

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